Coden : Ijpnl 6 Qsar Modeling Studies on 2 , 4 - Thiazolidinediones as Potential Α - Glucosidase Inhibitors
نویسندگان
چکیده
A linear quantitative structure-activity relationship (QSAR) model is presented for modeling and predicting the αglucosidase inhibitory activity. The model was produced by using the multiple linear regression (MLR) technique on a twenty one compound database that consists of newly discovered 2,4-thiazolidinediones. The major conclusion of this study is that molecular weight, wiener index, andrews affinity and polar surface area affect significantly the αglucosidase inhibitory activity by 2,4-thiazolidinediones. The selected QSAR descriptors serve as a primary guidance for the design of novel and selective α-glucosidase inhibitors.
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